Female guppies need to be isolated when giving birth to fry. This is because guppies are known to practice cannibalism where larger fish eat the smaller ones. To protect the fry, once the female guppy has given birth, the adult fish and the fry must be raised separately.

Reasons for Isolation
Protecting the Fry: Larger fish will eat the smaller ones. To protect the fry from being harmed, isolation is necessary.
Stable Water Environment: Keeping them separately can maintain the stability of the water environment. It's best to use the water from the original fish tank.
Nutritional Requirements: After giving birth, the female guppy needs proper nutrition. Live foods like daphnia are preferable for feeding. For the fry, they can be fed with egg yolk water in the first few days. After five days, they can be fed with powdered dry fish food or filtered daphnia.
Specific Methods of Isolation
Separate Rearing: Raise the adult fish and the fry separately to avoid the larger fish from eating the smaller ones.
Using the Water from the Original Fish Tank: To maintain the stability of the water environment, it's best to use the water from the original fish tank.
Feeding: After giving birth, the female guppy needs proper nutrition. Live foods like daphnia are preferable for feeding. For the fry, they can be fed with egg yolk water in the first few days. After five days, they can be fed with powdered dry fish food or filtered daphnia.