The treatment methods for the Saprolegniasis of Koi mainly include measures such as drug treatment, physical treatment, and water quality improvement.

Drug Treatment:
- Potassium permanganate: Use a potassium permanganate solution with a concentration of 1-2 ppm for a medicated bath. Each bath lasts for 20 minutes, once a day, for 3 consecutive days.
- Methylene blue: Conduct a medicated bath according to the proportion for 3-5 days. Replenish the medicine after changing the water every day.
- Malachite green: Apply an aqueous solution of malachite green with a concentration of 0.1%-1% to the wound and the area where the Saprolegnia attaches. Then soak the fish in a malachite green aqueous solution diluted at a ratio of 1:15000 for about 3-5 minutes.
- Mercurochrome: Apply 2% mercurochrome to the affected area.
- Oxytetracycline: Soak the diseased fish in an oxytetracycline solution.
- Japanese yellow powder or Saprolegniasis Remover: Sprinkle the whole fish tank with the dosage specified in the instruction manual.
Physical Treatment:
- Raise the water temperature: Gradually increase the water temperature to 25-30°C to accelerate the metabolism of Koi and enhance their resistance.
- Add salt: Add 3%-5% salt to the water to change the osmotic pressure of the water body, reduce the burden on the kidneys of Koi, and prevent fungal attacks.
- Change the water: Change one-fifth of the water every other day to reduce the content of fungi in the water and improve the water quality.
Water Quality Improvement:
- Regulate the water quality: Keep the water quality clean and avoid water quality deterioration. The most suitable water temperature for Koi is 20-28°C, which helps to enhance their immunity.
- Disinfect the fish tank: Thoroughly disinfect the fish tank. Use a potassium permanganate solution or a special aquatic disinfectant to effectively kill the latent mold spores.
Nutritional Support:
- Strengthen nutrition: Feed foods rich in high protein, vitamins, and minerals to improve the physical condition of Koi and enhance their ability to resist diseases.